Vytrus Biotech, the company specialized in active ingredients derived from plant biotechnology for skin and hair care, has recently launched its biotechnological active ingredient CLARIVINE™ - Fasting for Skin Longevity, a finalist in the Innovation Awards of in-cosmetics Global 2025.
With a unique biomimetic mechanism that reflects cellular fasting in the skin, Vytrus has developed a 100% natural active that mimics the effects of intermittent fasting at the cellular level, triggering a rejuvenating and detoxifying process that achieves the glass skin effect while improving long-term resilience.
This innovative ingredient will be presented by the Vytrus team at in-cosmetics Global in Amsterdam, from April 8 to 10, Hall 1 stand 1E60. The company will also showcase its latest research on plant exosomes for skin and hair care applications through biotechnology, reaffirming its leadership in plant stem cell innovation.
CLARIVINE™ aligns with a growing trend in the industry where exosomes, biotechnological advances, and award-nominated actives converge. Vytrus was one of the first companies to demonstrate the presence of natural plant exosomes in 2024, with previous actives like CENTELLA REVERSA™ and CAPILIA LONGA™ nominated for the BSB Innovation Awards 2025, whose award ceremony will also take place on April 8 in Amsterdam.
CLARIVINE™ introduces an innovative biological approach to promote skin longevity by mimicking the molecular effects of cellular fasting. This mechanism activates key regenerative pathways that improve texture, tone, dark spots, and skin pigmentation, while enhancing hydration and the appearance of wrinkles in just 14 days. The result is an immediate effect of illumination, rejuvenation, and smoothing, the coveted glass skin appearance, combined with scientifically proven cellular longevity benefits, clinically validated in multi-ethnic panels of Asian and Caucasian volunteers.
CLARIVINE™ is 100% natural (ISO 16128), COSMOS approved, compliant with China, Halal certified, and compatible and respectful of the microbiome.
Plant fasting factors: a new approach to healthy skin aging
Fasting has been recognized for its systemic health and longevity benefits. Vytrus's research and product development aimed to transfer this principle to the skin, not through diet, but through cosmetics, and it was clinically demonstrated for the first time in cosmetics.
Vytrus has developed a unique approach that mimics fasting for the skin, inspired by the science of cellular fasting. This is achieved by inducing a hormetic response in the stem cells of Vitis vinifera through controlled nutrient deprivation. This mild stress stimulates plant cells to produce a secretome rich in resilience bioactive compounds, which Vytrus defines as Plant Fasting Factors, a key concept in skin longevity biology composed of:
- Polyphenols and secondary metabolites
- Signaling peptides and proteins
- Natural plant exosomes rich in exosomal peptides and resveratrol exosome
These factors activate crucial regenerative pathways such as autophagy, telomere protection, and reduction of oxidative stress, improving cellular performance and promoting healthy aging from within. Skin cells gently enter a rejuvenation mode, detoxifying and renewing themselves naturally.
An innovation inspired by plant longevity
CLARIVINE™ is derived from the stem cells of Vitis vinifera, a perennial plant known for its extraordinary lifespan and regenerative capacity. Vines can live for centuries, and the secret to their resilience lies in their ability to adapt to environmental stress.
Vytrus has harnessed this natural intelligence by applying a intermittent fasting protocol to vine stem cells, stimulating them to produce a potent fasting-induced secretome. The result is a cutting-edge cosmetic active that unites two powerful skin care trends: the quest for longevity and the pursuit of glass skin.
CLARIVINE™ represents a new frontier in skin care, offering cosmetic formulators a sustainable plant-based solution for:
- Soothing, illuminating, and radiance-enhancing formulations
- Skin tone unifying and pigmentation-reducing treatments
- Anti-wrinkle applications and hydration enhancers • Glass skin products for long-term healthy aging